Vitamin B12 Protects from Thiol Antioxidant Toxicity

Vitamin B12 Protects from Thiol Antioxidant Toxicity

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A team of researchers at the Indian Institute of Science Education and Research Mohali has revealed that the thiol reducing agent Dithiothreitol (DTT) causes toxicity
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Scientists Untangle Brain Disorder Mystery Impacting Therapeutic Enigma

Scientists Untangle Brain Disorder Mystery Impacting Therapeutics Enigma

Using the Drosophila as a model, scientists have provided new insights for the development of therapeutics for targeting a gene, Ataxin-2.

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A Blueprint to Develop A Rapid qRT-PCR kit To Detect SARS-CoV-2

A Blueprint to Develop A Rapid qRT-PCR kit To Detect SARS-CoV-2

Researchers at the Advanced Centre for Treatment, Research, and Education in Cancer have published a report in the Cell Press journal ‘Heliyon’ in which they present a Rapid qRT-PCR kit To Detect SARS-CoV-2

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E-Science Predicts Potential Anti-Coronaviral Drugs and Vaccine Candidates

E-Science Predicts Potential Anti-Coronaviral Drugs and Vaccine Candidates

Using bioinformatics approaches, the research team has succeeded in identifying 38 anti-coronaviral drugs from a pool of antiviral drug candidates.

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Asthma Medicine Mode of Action Revealed

Asthma Medicine Mode of Action Revealed

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In a research article published in Nature, a team of researchers including Prof. Arun Shukla’s laboratory at IIT Kanpur, describe the structure of an asthma drug in complex with its target receptor and a regulatory protein in action.
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Researchers Develop New Method of Supporting Ultra Small Metal Nanoparticles on Silica

Researchers Develop New Method of Supporting Ultra Small Metal Nanoparticles on Silica

A research team at CSIR-National Chemical Laboratory, Pune - has developed a new method that could overcome the difficulties of supporting ultra-small metal nanoparticles on silica with desirable loading.

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Designer Biosensors to Probe the Activation of Important Drug Targets

Designer Biosensors to Probe the Activation of Important Drug Targets

Researchers from IIT Kanpur have engineered antibody-based biosensors in the laboratory using protein-design approaches. These biosensors report the activation of important drug targets, and the approach used in this study also offers new solutions to the long-standing challenge of generating high-quality antibodies for life science research

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A New Paradigm for Better Drug Discovery Targeting GPCRs

A New Paradigm for Better Drug Discovery Targeting GPCRs

Researchers from the Indian Institute of Technology-Kanpur have found structural differences between beta-arrestin Isoforms 1 and 2 upon their interaction with receptors. Beta-arrestin is a cellular protein that acts as a universal regulator of GPCRs, and this finding may help in designing novel therapeutic targets.

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Novel Therapeutic Possibility for Inflammatory Disorders

Novel Therapeutic Possibility for Inflammatory Disorders

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Scientists have identified a synthetic peptide C5apep derived from and modified based on, C5a sequence- may provide an alternative therapeutic candidate compared to currently used ligands
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“Gut feelings” of worms might help in understanding sickness behavior in humans

“Gut Feelings” of Worms Might Help Understand Sickness Behavior

Researchers have shown that in worms bloating of the gut caused by pathogen infection helps both in recognition of pathogenic bacteria and activation of defence mechanisms

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New Technology May Help Engineer Natural Proteins in Human Body

New Technology May Help Engineer Natural Proteins in Human Body

Dr. Vishal Rai’s team at Indian Institute of Science Education and Research Bhopal- provides the first modular platform for precision engineering of native proteins. The study was published in the Journal of the American Chemical Society

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Scientists Present New Regulatory Clues to Mammalian Cell Division

Scientists Present New Regulatory Clues to Mammalian Cell Division

Researchers have revealed the regulatory role of a protein in the process of cell cycle progression and separation of newly formed mammalian cells. This study may help to understand uncontrolled cell division related cues because many regulatory proteins of the cell cycle, such as the one that reported in this study, are mutated in cancer cells.

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Tomato Gene Involved in Viral Infection and Heat Stress Identified

Tomato Gene Involved in Viral Infection and Heat Stress Identified

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Scientists at New Delhi-based National Institute of Plant Genome Research have deciphered the critical role of a single gene - SlDEAD35 - in tomato plant whose expression controls its response to both heat stress and viral infection
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Balancing Act at The Edge of Cells

Balancing Act at The Edge of Cells

The study done by lead author Joseph Jose Thottacherry shows that the CG endocytosis is intimately connected to membrane tension by sensing and responding to changes in membrane tension

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New Polymeric Material Developed for Controlled Release of Two Different Drugs

New Polymeric Material Developed for Controlled Release of Two Different Drugs

A team of researchers at Indian Institute of Technology, Guwahati has developed a biocompatible polymeric material that promises to help in the simultaneous and extended release of two different drugs from a single platform

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Injectable Gel May Deliver Islet Cells for Type 1 Diabetes

Injectable Gel May Deliver Islet Cells for Type 1 Diabetes

Researchers at the Indian Institute of Technology, Guwahati have developed an injectable gel using silk proteins to deliver insulin-producing cells needed to address type1 diabetes

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Scientists Open New Avenue to Study Head Muscle Dystrophy

Scientists Open New Avenue to Study Head Muscle Dystrophy

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Indian researchers have identified the mechanism by which muscles above the neck, known as head muscles, are formed during development of an embryo in the womb
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Scientists Unravel Mysteries of Human Brain in an Open Day to Lay Public

Scientists Unravel Mysteries of Human Brain in an Open Day to Lay Public

In order to educate the general public about scientific research and its benefits, DBT-National Brain Research Centre, Manesar - organized an Open Day on September 20, 2018, under India International Science Festival 2018 (IISF) banner

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Experiments in Rats Show Some Bad Memories Can Be Forgotten

Experiments in Rats Show Some Bad Memories Can Be Forgotten

Indian scientists have shown that exaggerated response and difficulty to get rid of bad memories could depend on whether the bad memory was formed before or after a stressful event

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New Approach Can Make Better Titanium Alloy for Implants

Researchers at the Indian Institute of Science in Bengaluru have proposed a new approach for developing orthopedic implants with better ability to bond with the bone

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Scientists Find Protein Role in Muscle Disease

Scientists Find Protein Role in Muscle Disease

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A research team led by Dr. Linda M. Hendershot and Viraj P. Ichhaporia at St. Jude Children’s Research Hospital, USA, has recently shown that the genetic loss of SIL1 disrupts Endoplasmic Reticulum (ER) homeostasis, leading to a condition of muscle disease
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Scientists Find Protein Role in Tuberculosis Bacteria Growth

Scientists Find Protein Role in Tuberculosis Bacteria Growth

Researchers at the National Institute of Immunology in collaboration with CSIR- Institute of Genomics and Integrative Biology have determined the role of FtsQ, a critical cell division protein and shown that both increasing and decreasing amounts of this protein in Mycobacterium tuberculosis hampers its growth and division patterns

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Drs. Neetu Kalra, Vishal Rai, Sanjeev Shukla, Maheshwer reddy Chilamari (Left to Right)

Scientists Develop New Method to Synthesize Bio-Conjugates

In a promising development in the area of targeted treatment of cancer, a team of researchers at the Indian Institute of Science Education and Research (IISER), Bhopal, have developed a new method to synthesize antibody-drug conjugates (ADC) using the chemical route.

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Scientists Provide New Insight into Basophils Activation

Scientists Provide New Insight into Basophils Activation

Dr. Jagadeesh Bayry’s  team at Institut National de la Santé et de la Recherche Médicale (French National Institute of Health and Medical Research, INSERM), Paris, France- have discovered that Tregs instead of suppressing the activities of basophils, they trigger these cells to express  activation markers, to secrete cytokines and support their allergic responses.

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Artificial Membrane Inspired by Fish Scales May Help in Cleaning Oil Spills

Artificial Membrane Inspired by Fish Scales May Help in Cleaning Oil Spills

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Fish scales have a typical structure and chemistry that makes them naturally capable of repelling oil. Scientists are trying to exploit this property for developing novel materials that can find application in addressing oil pollution.
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Metal-Organic Nano Sheets May Help Develop Novel Lens Material

Metal-Organic Nano Sheets May Help Develop Novel Lens Material

Photochromic materials can change color under stimulation of light. They are of high commercial importance for ophthalmic lens industry as also in sectors like optoelectronic switching devices, data storage, and optical transmission.

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Scientists Find Synthetic Mimic For Critical Biomolecule

Biological assemblies are thousands of tiny pieces of machinery which play collectively important roles towards maintaining the cellular structure and functions, and many of them even play very critical roles.

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Glycogen in Neurons of Degenerating Brains Is Beneficial

Glycogen in Neurons of Degenerating Brains Is Beneficial

A team of Indian scientists has figured out that glycogen in neurons actually has a protective role in patients with neurodegenerative disorders like Alzheimer's and Huntington's.

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Scientists Shed Light on Cancer Risk Associated With Epigenetic Changes during Aging

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The new science of Epigenetics has enabled us to track, how our lifestyle and surroundings affect the behavior of genes in our body, without altering the underlying DNA sequence (commonly called ‘mutations’).
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Scientists are looking into Fruit Flies to Understand the Biology of Taste

Scientists are looking into Fruit Flies to Understand the Biology of Taste

Have you ever wondered why candies taste so good and pill so bitter? It seems the secret lies in one pair of brain cells.

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