The scope for developing a new vaccine against the dreaded disease of Tuberculosis through the biological route has become brighter, with researchers at Kolkata-based Indian Institute of Chemical Biology (IICB) and Bose Institute identifying a potential trouble spot and figuring out ways to deal with it.
Dr. Jagadeesh Bayry’s team at Institut National de la Santé et de la Recherche Médicale (French National Institute of Health and Medical Research, INSERM), Paris, France- have discovered that Tregs instead of suppressing the activities of basophils, they trigger these cells to express activation markers, to secrete cytokines and support their allergic responses.
By altering the intracellular protein modification with sugar, Dr. Kuo-I Lin’s lab made B cells in mice turn lethargic when they reach a mature age and mount the antibody responses.
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