A Path-Breaking Research for Safer Pregnancy Drugs

A Path-Breaking Research for Safer Pregnancy Drugs

  • Research Stash
  • News
  • 1.4K

There was a tragic event that shook the world in the 1960s when a large number of babies were born with severe deformities whose mothers had been prescribed a drug called ‘thalidomide’ for morning-sickness.  “The problem was a result of the consumption of two enantiomers without separation. One of the isomers was toxic, while the other was the drug”, says Prof. A. S. Achalkumar, Department of Chemistry, IIT Guwahati. Prof Achalkumar and Prof. Yasuhiro Ishida from RIKEN, Wako-shi campus, Japan, have developed a simple and novel method to separate chiral enantiomers.

Chiral enantiomers are chemicals that have the same molecular formula but the different three-dimensional arrangement of the constituent molecular segments. The separation of enantiomers is significant in the bio-medical field because many biochemically active chemicals are found as mixtures of two enantiomers, one of which may be beneficial and the other, toxic.

The chemical properties of enantiomers are similar, which makes it very difficult to separate them or to synthesize specifically one without being contaminated from the other enantiomer. “Nature is master in the exclusive production of enantiomerically pure amino acids and sugars, but man is still trying to master the art of enantioselective synthesis”, observes Prof Achalkumar. The current method to separate enantiomers is by chromatography, which is slow, energy-intensive, and requires environmentally harmful solvents.

The researchers have separated enantiomers with the use of helical supramolecular polymers.  The helical polymers are formed by the salt formation of aromatic carboxylic acid and chiral amino alcohols. In this simple one-pot process they could resolve racemic mixtures into materials rich in one isomer.

The interaction sites in supramolecular polymer not only help in the connection of the monomers but also in the recognition of chiral guests. When two salts with the same chirality are mixed, they undergo copolymerization and became soluble, while those with opposite chirality do not form copolymer and hence precipitate. The precipitated compound can be separated easily. The present system can be used for the enantioseparation of the abundant class of chiral amino alcohols, which has huge commercial potential.”

Prof. Ishida adds that although many supramolecular polymers are known, their enantio-separation ability has never been investigated so far. “Development of such process may help in reducing the price of chiral active pharmaceutical ingredients (APIs) and finally that of the medical treatment, itself. In addition, such a process can be extended to other classes of chiral molecules”, he says.

The group of researchers is led by Prof. A. S. Achalkumar, and Prof. Yasuhiro Ishida from RIKEN, Wako-shi campus, Japan. Their path-breaking work has recently been published in the prestigious journal, Nature Communications. The paper has been co-authored by Prof. Achalkumar, Prof. Ishida, Dr. Vakayil Praveen, Senior Scientist, CSIR-National Institute for Interdisciplinary Science and Technology, and research scholars Dr. Krishnachary Salikolimi, Ms. Kuniyo Yamada, and Dr. Noriko Horimoto. The research findings have been published in the journal, Nature Communications. (ISW)

If you liked this article, then please subscribe to our YouTube Channel for the latest Science & Tech news. You can also find us on Twitter & Facebook

Rate

The researchers have separated enantiomers with the use of helical supramolecular polymers.  The helical polymers are formed by the salt formation of aromatic carboxylic acid and chiral amino alcohols. In this simple one-pot process they could resolve racemic mixtures into materials rich in one isomer.

The interaction sites in supramolecular polymer not only help in the connection of the monomers but also in the recognition of chiral guests. When two salts with the same chirality are mixed, they undergo copolymerization and became soluble, while those with opposite chirality do not form copolymer and hence precipitate. The precipitated compound can be separated easily. The present system can be used for the enantioseparation of the abundant class of chiral amino alcohols, which has huge commercial potential.”

Prof. Ishida adds that although many supramolecular polymers are known, their enantio-separation ability has never been investigated so far. “Development of such process may help in reducing the price of chiral active pharmaceutical ingredients (APIs) and finally that of the medical treatment, itself. In addition, such a process can be extended to other classes of chiral molecules”, he says.

The group of researchers is led by Prof. A. S. Achalkumar, and Prof. Yasuhiro Ishida from RIKEN, Wako-shi campus, Japan. Their path-breaking work has recently been published in the prestigious journal, Nature Communications. The paper has been co-authored by Prof. Achalkumar, Prof. Ishida, Dr. Vakayil Praveen, Senior Scientist, CSIR-National Institute for Interdisciplinary Science and Technology, and research scholars Dr. Krishnachary Salikolimi, Ms. Kuniyo Yamada, and Dr. Noriko Horimoto. The research findings have been published in the journal, Nature Communications. (ISW)

If you liked this article, then please subscribe to our YouTube Channel for the latest Science & Tech news. You can also find us on Twitter & Facebook

" }

MOST, Taiwan unveils plan for AI research centers

The Ministry of Science and Technology unveiled plans July 6 to establish up to four artificial intelligence innovation research centers across Taiwan as part of government efforts to enhance the nation’s competitiveness in AI technology.

  • News
  • 2.2K
Read more

Understanding Positioning System of Cells May Help Unravel Key Diseases

A team of researchers led by Dr. Padinjat Raghu at National Centre for Biological Sciences, Bengaluru have shown that signals present within RDGB protein determine if it will remain in a specific compartment of the cell for it to function normally

  • News
  • 1.9K
Read more
Astronomers Detect for First Time Light from Very First Stars of Universe

Astronomers Detect for First Time Light from Very First Stars of Universe

A team of astronomers including an Indian graduate student Nivedita Mahesh from Arizona State University have discovered for the first time signals from “cosmic dawn” - the moment when the universe's earliest stars emerged, making a significant breakthrough in our understanding of the evolution of cosmos.

  • News
  • 2.9K
Read more

Internet is huge! Help us find great content

Newsletter

Never miss a thing! Sign up for our newsletter to stay updated.

About

Research Stash is a curated collection of tools and News for S.T.E.M researchers

Have any questions or want to partner with us? Reach us at hello@researchstash.com

Navigation

Submit